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产品名称:abcam白介23抗体Anti-IL23 antibody

产品型号:abcam ab115759

产品报价:

产品特点:Product name Anti-IL23 antibody
Tested applicationsWB, IHC-P, ICCmore details

abcam ab115759abcam白介23抗体Anti-IL23 antibody的详细资料:

Product nameAnti-IL23 antibodySee all IL23 products (5) ...

  • Description
    Rabbit polyclonal to IL23
  • Tested applicationsWB, IHC-P, ICCmore details
  • Cross reactivity
    Reacts with: Mouse, Human
  • Immunogen

    A 16 amino acid synthetic peptide conjugated to KLH, corresponding to the C-terminus of Human IL23.

  • Positive controlHuman Kidney, Mouse brain, Mouse kidney and Mouse liver tissues

Properties

  • FormLiquid
  • Storage instructionsStore at +4°C.
  • Storage bufferPreservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration50 µg at 1 mg/ml
  • PurityImmunogen affinity purified
  • Clonality Polyclonal
  • IsotypeIgG
  • Research Areas
    • Cancer
    • Tumor immunology
    • Cytokines
    • Interleukins
    • Immunology
    • Innate Immunity
    • Cytokines
    • Interleukins

Applications

Our Abpromise guarantee covers the use of ab115759 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 2 - 4 µg/ml. Predicted molecular weight: 21 kDa.
IHC-P IHC-P: Use a concentration of 5 µg/ml. Perform heat ted antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC ICC: Use at an assay dependent dilution.

Target

  • FunctionAssociates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
  • Tissue specificitySecreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
  • Sequence similaritiesBelongs to the IL-6 superfamily.
  • Developmental stageExpressed by newborns dendritic cells.
  • Cellular localizationSecreted. Secreted upon association with IL12B.
  • Inion by UniProt
  • Database links
    • Entrez Gene: 51561 Human
    • Entrez Gene: 83430 Mouse
    • Entrez Gene: 83430 Mouse
    • Omim: 605580 Human
    • SwissProt: Q9NPF7 Human
    • SwissProt: Q9EQ14 Mouse
    • SwissProt: Q9EQ14 Mouse
    • Unigene: 98309 Human
    • Unigene: 382212 Human
    • Unigene: 98309 Human
    • Unigene: 125482 Mouse
    • Unigene: 125482 Mouse
    see all
  • Alternative names
      IL 23 antibodyIL 23A antibodyIL-23 subunit alpha antibody
      IL-23-A antibodyIL-23p19 antibodyIL23 antibodyIl23a antibodyIL23A_HUMAN antibodyIL23P19 antibodyInterleukin 23 alpha subunit p19 antibodyInterleukin 23 p19 subunit antibodyInterleukin-23 subunit alpha antibodyInterleukin-23 subunit p19 antibodyJKA3 induced upon T cell activation antibodyMGC79388 antibodyP19 antibodySGRF antibody
    see all

Anti-IL23 antibody images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL23 antibody (ab115759)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL23 antibody (ab115759)
    Human Kidney (formalin-fixed, paraffin-embedded) stained with ab115759 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL23 antibody (ab115759)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL23 antibody (ab115759)
    Mouse Brain (formalin-fixed, paraffin-embedded) stained with ab115759 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL23 antibody (ab115759)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL23 antibody (ab115759)
    Mouse Kidney (formalin-fixed, paraffin-embedded) stained with ab115759 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL23 antibody (ab115759)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL23 antibody (ab115759)
    Mouse Liver (formalin-fixed, paraffin-embedded) stained with ab115759 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-IL23 antibody (ab115759)

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