博九彩票

产品展示
当前位置:首页 > 产品中心 > 细胞培养因子 > R&D细胞因子 > 314-ml-025RD重组human IL-17A人白介17A细胞生长因子

产品名称:RD重组human IL-17A人白介17A细胞生长因子

产品型号:314-ml-025

产品报价:

产品特点:RD重组human IL-17A人白介17A细胞生长因子
Source E. coliderived
此产品还有小鼠IL-17A

314-ml-025RD重组human IL-17A人白介17A细胞生长因子的详细资料:

RD重组human IL-17A人白介17A细胞生长因子

DESCRIPTION
Source E. coliderived
Thr22Ala158
Accession # Q62386.1
Nterminal
Sequence
Analysis
Thr22
Structure / Form Disulfidelinked
homodimer
Predicted Molecular
Mass
15.5 kDa (monomer)
SPECIFICATIONS
Activity Measured by its ability to induce IL6
secretion by NIH-3T3 mouse embryonic fibroblast cells. Yao, Z. et al. (1995) Immunity 3:811.
The ED50 for this effect is typically 0.251.25
ng/mL.
Endotoxin Level <1.0 EU per 1 μg of the protein by the LAL method.
Purity >97%, by SDSPAGE
under reducing conditions and visualized by silver stain.
Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein. See Certificate of Analysis for details.
PREPARATION AND STORAGE
Reconstitution Reconstitute at 25 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it imy at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freezethaw
cycles.
l 12 months from date of receipt, 20
to 70
°C as supplied.
l 1 month, 2 to 8 °C under sterile conditions after reconstitution.
l 3 months, 20
to 70
°C under sterile conditions after reconstitution.
BACKGROUND
Interleukin 17 (also known as CTLA8)
is a T cellexpressed
pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of
herpesvirus Saimiri. cDNA clones encoding IL17
have been isolated from activated rat, mouse and human T cells. Mouse IL17
cDNA encodes a 158 amino acid (aa)
residue precursor protein with a 21 amino acid residue signal peptide that is cleaved to yield the 137 aa residue mature IL17.
Both recombinant and natural IL17
have
been shown to exist as disulfide linked homodimers. At the amino acid level, mIL17
shows 57% and 87% sequence identity with herpesvirus and rat IL17,
respectively. An IL17
specific mouse cell surface receptor (IL17
R) has been cloned. While the expression of IL17
mRNA is restricted to activated alpha beta
TCR+CD4CD8T
cells, the expression of mIL17
R mRNA has been detected in virtually all cells and tissues tested. IL17
exhibits multiple biological activities on a
variety of cells including: the induction of IL6
and IL8
production in fibroblasts? the enhancement of surface expression of ICAM1
in fibroblasts? activation of NFκB
and costimulation of T cell proliferation.
References:
1. Kennedy, J. et al., (1996) J. Interferon Cytokine Res. 16:611.
2. Yao, Z. et al., (1995) J. Immunol. 155:5483.
3. Yao, Z. et al., (1995) Immunity 3:811.
4. Rouvier, E. et al., (1993) J. Immunol. 150:5445.

RD Recombinant human IL-17A人白介17因子 详细产品信息可和选购

RD重组human IL-17A人白介17A细胞生长因子

RD Recombinant human IL-17A人白介17因子 详细产品信息可和选购

 如果你对314-ml-025RD重组human IL-17A人白介17A细胞生长因子感兴趣,想了解更详细的产品信息,填写下表直接与厂家联系:

留言框

  • 产品:

  • 留言内容:

  • 您的单位:

  • 您的姓名:

  • 联系电话:

  • 常用邮箱:

  • 详细地址:

  • 省份:

  • 验证码:

    请输入计算结果(填写阿拉伯数字),如:三加四=7
上一篇:RD代理,RD细胞因子,RD现货,RD-systems中国一级代理 下一篇:L7757sigma利多卡因Lidocaine现货供应

免责声明: 本站资料及图片来源互联网文章,本网不承担任何由内容信息所引起的争议和法律责任。所有作品版权归原创作者所有,与本站立场无关,如用户分享不慎侵犯了您的权益,请联系我们告知,我们将做删除处理!