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当前位置:首页 > 产品中心 > 胎牛血清培养基细胞因子 > peprotech细胞因子 > 100-21Peprotech重组人TGF-beta1细胞因子Recombinant Human TGF-β1

产品名称:Peprotech重组人TGF-beta1细胞因子Recombinant Human TGF-β1

产品型号:100-21

产品报价:1

产品特点:Peprotech重组人TGF-beta1细胞因子Recombinant Human TGF-β1

100-21Peprotech重组人TGF-beta1细胞因子Recombinant Human TGF-β1的详细资料:

Peprotech重组人TGF-beta1细胞因子Recombinant Human TGF-β1

产品编号:

100-21

别名:

Transforming Growth Factor-β1, Differentiation inhibiting factor, Cartilage-inducing factor

描述:

The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conional changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transion of fibroblasts, and recently it has been implicated in the ion of skin tumors. Recombinant Human TGF-β1 derived from HEK293 cells is a 25.0 kDa protein with each subunit containing 112 amino acid residues, linked by a single disulfide bond.

Peprotech重组人TGF-beta1细胞因子Recombinant Human TGF-β1

氨基酸序列:

ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS

来源:

HEK293 cells

纯度:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

生物活性:

The ED50 was determined by TGF-beta1's ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.

交叉反应:

Chicken, Cow, Dog, Frog, Monkey, Mouse, Pig, Rabbit, Rat, Human, Mink, Donkey, N/A, Mouse + Virus

Peprotech重组人TGF-beta1细胞因子Recombinant Human TGF-β1

 

研究领域:

血管生成/ 心血管血管生成/ 心血管细胞凋亡细胞凋亡
癌症癌症免疫系统免疫系统
炎症炎症增殖增殖
干细胞及分化干细胞及分化TGF超家族TGF超家族
创伤修复创伤修复过敏过敏

原产国:

USA

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